F-Amidine (trifluoroacetate salt)

An irreversible inhibitor of arginine deiminase (PAD).
Catalog #: B2803 | abID:

Product Details

Alternate Name N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-benzamide, 2,2,2-trifluoroacetate
N-[(2S)-1-amino-5-[(1-amino-2-fluoroethylidene)amino]-1-oxopentan-2-yl]benzamide;2,2,2-trifluoroacetic acid
Appearance Solution in methanol
CAS # 877617-46-4
Molecular Formula C₁₆H₂₀F₄N₄O₄
Molecular Weight 408.35
Purity ≥95%
Solubility 20 mg/ml in DMSO and DMF
30 mg/ml in Ethanol
InChi InChI=1S/C14H19FN4O2.C2HF3O2/c15-9-12(16)18-8-4-7-11(13(17)20)19-14(21)10-5-2-1-3-6-10;3-2(4,5)1(6)7/h1-3,5-6,11H,4,7-9H2,(H2,16,18)(H2,17,20)(H,19,21);(H,6,7)/t11-;/m0./s1
PubChem CID 11589583
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


F-Amidine (trifluoroacetate salt) is an irreversible inhibitor of protein arginine deiminase (PAD). The in vitro IC₅₀ values are 29.5 µM, 350 µM, and 21.6 µM for PAD1, PAD3 and PAD4, respectively. The IC₅₀ for cytoxicity in HL-60, MCF-7, and HT-29 cancer cell lines is 0.5 μM, 0.5 μM and 1 μM, respectively.

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