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EZSolution™ Torin 2

A potent mTOR inhibitor
Catalog #: 2354
$125.00

Product Details

Cat # +Size 2354-5
Size 5 mg
Alternate Name 9-(6-Amino-3-pyridinyl)-1-[3-(trifl­uoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)­-one
Appearance Liquid
Formulation A 10 mM solution in DMSO
CAS # 1223001-51-1
Molecular Formula C₂₄H₁₅F₃N₄O
Molecular Weight 432.4
Purity ≥98% by HPLC
SMILES C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F
InChi InChI=1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
InChi Key GUXXEUUYCAYESJ-UHFFFAOYSA-N
PubChem CID 51358113
MDL Number MFCD18782652
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent, selective and ATP-competitive mTOR inhibitor (IC₅₀ = 2.1 nM for mTORC1). Torin 2 displays 800-fold selectivity for mTOR over PI3K (cellular EC₅₀ values of 0.25 nM and 200 nM, respectively) and exhibits 100-fold binding selectivity relative to 440 other protein kinases.


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