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EZSolution™ Torin 1

A potent mTOR inhibitor
Catalog #: 2353
$135.00

Product Details

Cat # +Size 2353-5
Size 5 mg
Alternate Name 1-[4-[4-(1-Oxopropyl)-1-piperazinyl­]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benz­o[h]-1,6-naphthyridin-2(1H)-one
Appearance Liquid
Formulation A 10 mM solution in DMSO
CAS # 1222998-36-8
Molecular Formula C₃₅H₂₈F₃N₅O₂
Molecular Weight 607.62
Purity ≥98% by HPLC
SMILES CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F
InChi InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
InChi Key AKCRNFFTGXBONI-UHFFFAOYSA-N
PubChem CID 49836027
MDL Number MFCD18782653
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent, selective and ATP-competitive mTOR inhibitor, with IC₅₀ values of 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 displays 1000-fold selectivity for mTOR over PI3K (EC₅₀ = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases.


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