Product Details
| abID | ab146606 |
|---|---|
| Cat # +Size | 2541-5 |
| Size | 5 mg |
| Alternate Name | 2-Hydroxy-4-[[[[4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid; NSC 74859; S3I-201 |
| Appearance | Liquid |
| Formulation | A 10 mM solution in anhydrous DMSO |
| CAS # | 501919-59-1 |
| Molecular Formula | C₁₆H₁₅NO₇S |
| Molecular Weight | 365.36 |
| Purity | ≥97% by HPLC |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O |
| InChi | InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21) |
| InChi Key | HWNUSGNZBAISFM-UHFFFAOYSA-N |
| PubChem CID | 252682 |
| MDL Number | MFCD09907564 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Inhibits Stat3.Stat3 complex formation and Stat3-DNA binding activity in vitro (IC₅₀ = 86 ± 33 µM) and Stat3-dependent transcriptional activities. S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo.
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