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EZSolution™ SCD1 Inhibitor

A SCD1(stearoyl-CoA desaturase 1 inhibitor
Catalog #: 2548
$145.00

Product Details

Cat # +Size 2548-1
Size 1 mg
Alternate Name 4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide
Appearance Liquid
Formulation A 10 mM solution in anhydrous DMSO
Molecular Formula C₂₀H₂₂ClN₃O₃
Molecular Weight 387.86
Purity ≥95% by HPLC
SMILES CNC(=O)C1=CC(=CC=C1)NC(=O)N2CCC(CC2)OC3=CC=CC=C3Cl
InChi InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)
InChi Key DPYTYQFYDLYWHZ-UHFFFAOYSA-N
PubChem CID 24905400
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC₅₀ = 37 nM for hSCD1, <4 nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterations in macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists.


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