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EZSolution™ Nec-1s

A potent necroptosis inhibitor
Catalog #: 2535
$70.00

Product Details

Cat # +Size 2535-1
Size 1 mg
Alternate Name 5-((7-Cl-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione); 7-Cl-O-Nec-1
Appearance Liquid
Formulation A 10 mM solution in anhydrous DMSO
Molecular Formula C₁₃H₁₂ClN₃O₂
Molecular Weight 277.71
Purity ≥96% by LC-MS
SMILES CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
InChi InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)
InChi Key WIKGAEMMNQTUGL-UHFFFAOYSA-N
PubChem CID 643953
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent necroptosis inhibitor. Displays higher activity in inhibiting necroptosis in Jurkat cells than Nec-1 (Cat. No. 1864) (EC₅₀ = 210 nM versus EC₅₀ = 490 nM), as well as showing no nonspecific cytotoxicity at high concentrations (~100 mM). More useful for in-cell and in vivo experiments compared to Nec-1.


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