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EZSolution™ GW2580

A cFMS kinase inhibitor
Catalog #: 2549

In stock

$85.00

Product Details

Cat # +Size 2549-5
Size 5 mg
Alternate Name 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
Appearance Liquid
Formulation A 10 mM solution in anhydrous DMSO
CAS # 870483-87-7
Molecular Formula C₂₀H₂₂N₄O₃
Molecular Weight 366.41
Purity ≥99% by HPLC
SMILES COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC
InChi InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
InChi Key MYQAUKPBNJWPIE-UHFFFAOYSA-N
PubChem CID 11617559
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 also inhibits lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro.


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