EZSolution™ GDC-0449

A Smoothened (Smo) antagonist
Catalog #: 2539 | abID:

Product Details

Cat # +Size 2539-5
Size 5 mg
Alternate Name 2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
Appearance Liquid
Formulation A 10 mM solution in anhydrous DMSO
CAS # 879085-55-9
Molecular Formula C₁₉H₁₄Cl₂N₂O₃S
Molecular Weight 421.3
Purity ≥98% by HPLC
SMILES CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
InChi InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
PubChem CID 24776445
MDL Number MFCD12407408
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.

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