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EZSolution™ AICAR

An AMPK activator
Catalog #: 2344

In stock

$125.00

Product Details

Cat # +Size 2344-50
Size 50 mg
Alternate Name N1-(β-D-Ribofuranosyl)-5-aminoimidaz­ole-4-carboxamide
Appearance Liquid
Formulation A 250 mM solution in D.I. water
CAS # 2627-69-2
Molecular Formula C₉H₁₄N₄O₅
Molecular Weight 258.23
Purity ≥98% by HPLC
SMILES C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N
InChi InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
InChi Key RTRQQBHATOEIAF-UUOKFMHZSA-N
PubChem CID 17513
MDL Number MFCD00869751
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells.


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