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EzH2 polyclonal antibody

Polyclonal Antibody to detect EZH2 in human and mouse samples.
Catalog #: 6838

Product Details

Cat # +Size 6838-25
Size 25 μg
Antibody Target EzH2
Alternate Name Enhancer of zeste homolog 2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Polyclonal antibody raised in rabbit against the N-terminus (aa1-343) of the mouse EZH2 protein (Enhancer of zeste homolog 2).
Accession # Q15910
Gene ID 2146
Appearance Colorless liquid
Formulation In PBS with 0.05% sodium azide and 0.05% ProClin 300.
Purification Protein G purified
Species Reactivity Human, mouse.
Application Western blot, ChIP, IHC.
Positive Control Western blot: HeLa cells, ChIP: HeLa cells, IHC.
Application & Usage ChIP: 2.5 µg/ChIP, Western Blot: 1:1000, IHC: 1:100 – 1:500.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


EZH2 is a histone-lysine methyltransferase which methylates ‘Lys-9’ and ‘Lys-27’ of histone H3, leading to transcriptional repression. It is a member of the polycomb group (PcG) family which form multimeric protein complexes and are involved in maintaining the transcriptional repressive state of genes over successive cell generations. The EZH2 activity is dependent on the association with other components of the PRC2 complex (EED, EZH2, SUZ12/JJAZ1, RBBP4 and RBBP7). EZH2 may play a role in the hematopoietic and central nervous systems. Over-expression of EZH2 is observed during advanced stages of prostate cancer and breast cancer.

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