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EZH2 Inhibitor, EPZ005687

A potent EZH2 inhibitor
Catalog #: 2364
SKU-Size Size Price Qty
2364-2 2 mg
$115.00
2364-10 10 mg
$395.00
More Sizes Get Quote

Product Details

Alternate Name 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide
Appearance White solid
CAS # 1396772-26-1
Molecular Formula C₃₂H₃₇N₅O₃
Molecular Weight 539.67
Purity ≥99%HPLC
Solubility DMSO
SMILES CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC=C(C=C4)CN5CCOCC5)C6CCCC6)C
InChi InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)
InChi Key ZOIBZSZLMJDVDQ-UHFFFAOYSA-N
PubChem CID 60160561
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent and selective inhibitor of histone lysine N-methyltransferase EZH2 (Ki = 24 nM). It displays more than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme, EZH1.


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