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Ezetimibe

A a cholesterol transport inhibitor
Catalog #: 9468

In stock

SKU-Size Size Price Qty
9468-25 25 mg
$75.00
9468-100 100 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name (3R,​4S)-​1,​4-​fluorophenyl-​3-​[(3S-​3-​4-​fluorophenyl)-​3-​hydroxypropyl]-​4-​(4-​hydroxyphenyl)-​2-​azetidinone
Appearance White solid
CAS # 163222-33-1
Molecular Formula C₂₄H₂₁F₂NO₃
Molecular Weight 409.43
Purity ≥98% by HPLC
Solubility DMSO (~15 mg/ml)
SMILES C1=CC(=CC=C1C2C(C(=O)N2C3=CC=C(C=C3)F)CCC(C4=CC=C(C=C4)F)O)O
InChi InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
InChi Key OLNTVTPDXPETLC-XPWALMASSA-N
PubChem CID 150311
MDL Number MFCD00937872
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ezetimibe is a cholesterol transport inhibitor. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. It exhibits IC50 values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids.


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