Product Details
| Alternate Name | Cytochrome P450 2D6, Cyt2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, Active CYP2D6, human cyp2d, recombinant CYP2D6, CYP2D6, CPD6, CYP2D, CYP2DL1, P450C2D, MGC120389, MGC120390, LKM1, liver/kidney microsomal antigen 1 |
|---|---|
| Gene Symbol | CYP2D6 |
| Gene ID | 1565 |
| Accession # | P10635 |
| Source | Pichia pastoris |
| Appearance | Dry powder |
| Physical Form Description | Lyophilized powder |
| Molecular Weight | 55 Kda |
| Purity by | NA |
| Endotoxin Level | NA |
| Biological Activity | NA |
| Reconstitution Instructions | 100 mM Potassium Phosphate buffer, pH 7.7 |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Cytochrome P450 2D6 (CYP2D6, EC 1.14.14.1) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are converted to more hydrophilic products to facilitate excretion from the body. CYP2D6 catalyzes oxidation of lipophilic bases with an aromatic ring and a nitrogen atom and is highly expressed in liver and brain tissue. The enzyme is responsible for metabolism of nearly 25% of all small molecule drugs commonly used by humans, particularly psychiatric drugs such as antidepressants, antipsychotics and stimulants. BioVision’s EZCyp™ 2D6 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP2D6 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.
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