EZCyp™ Active Human Cytochrome P450 2C9

Unique, cost-effective CYP2C9 catalytic system with active recombinant human CYP2C9 coexpressed with the active NADPH reductase in a semipermeable membrane system.
Catalog #: 7875 | abID:

Product Details

Alternate Name Cytochrome P450 2C, Cytochrome P450 2C9, Cyt2C9, CYPIIC, CYPIIC9, Cyp2c, Microsomal cytochrome P450 2C9, active CYP2C9, human cyp2c9, human CYP2C9, recombinant CYP2C, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9
Gene Symbol CYP2C9
Gene ID 1559
Accession # P11712
Source Pichia pastoris
Appearance Dry powder
Physical Form Description Lyophilized powder
Molecular Weight 55 Kda
Purity by NA
Endotoxin Level NA
Biological Activity NA
Reconstitution Instructions 25 mM Potassium Phosphate buffer, pH 7.7
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Cytochrome P450 2C9 (CYP2C9, EC is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are converted to more hydrophilic products to facilitate excretion from the body. In the liver, this enzyme contributes to the wide pharmacokinetic variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. CYP2C9 gene is highly polymorphic. More than 50 single nucleotide polymorphisms (SNPs) have been described in the regulatory and coding regions of the CYP2C9 gene, some of which are associated with reduced enzyme activity compared with wild type in vitro. Extrahepatic CYP2C9 often metabolizes endogenous compounds such as arachidonic acid, 5-hydroxytryptamine, and linoleic acid. BioVision’s EZCyp™ 2C9 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP2C9 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.

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