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EZCyp™ Active Human Cytochrome P450 2C19

Unique, cost-effective CYP2C19 catalytic system with active recombinant human CYP2C19 coexpressed with the active NADPH reductase in a semipermeable membrane system.
Catalog #: 7874
SKU-Size Size Price Qty
7874-10 10 mg
$125.00
7874-50 50 mg
$475.00
More Sizes Get Quote

Product Details

Alternate Name Cytochrome P450 2C, Cytochrome P450 2C19, Cyt2C19, CYPIIC, CYPIIC19, Cyp2c, Microsomal cytochrome P450 2C19, active CYP2C19, human cyp2c19, human CYP2C19, CPCJ, recombinant CYP2C, P450C2C, CYPIIC17, CYPIIC19, P450IIC19
Gene Symbol CYP2C19
Gene ID 1557
Accession # P33261
Source Pichia pastoris
Appearance Dry powder
Physical Form Description Lyophilized powder
Molecular Weight 55 Kda
Purity by NA
Endotoxin Level NA
Biological Activity NA
Reconstitution Instructions 50 mM Potassium Phosphate buffer, pH 7.7
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Cytochrome P450 2C19 (CYP2C19, EC 1.14.14.1) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are converted to more hydrophilic products to facilitate excretion from the body. CYP2C19 is primarily expressed in liver and intestinal tissue and catalyzes oxidation of neutral or weakly basic lipophilic molecules with 2-3 hydrogen bond donor/acceptor sites. Isoforms of the CYP2C subfamily are responsible for metabolism of nearly 20% of all small molecule drugs commonly used by humans. Polymorphisms in the human CYP2C19 gene have been implicated in clinical drug/drug interactions involving widely-prescribed drugs, including proton pump inhibitors, antiplatelet agents and anticonvulsants. BioVision’s EZCyp™ 2C19 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP2C19 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.


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