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EZCyp™ Active Human Cytochrome P450 1A2

Unique, cost-effective CYP1A2 catalytic system with active recombinant human CYP1A2 coexpressed with the active NADPH reductase in a semipermeable membrane system.
Catalog #: 7876
SKU-Size Size Price Qty
7876-10 10 mg
$125.00
7876-50 50 mg
$475.00
More Sizes Get Quote

Product Details

Alternate Name Cytochrome P450 1A, Cytochrome P450 1A2, Cyt1a2, CYPIA, CYPIA2, Cyp1A2, Microsomal cytochrome P450 1A2, active CYP1A2, human cyp1A2, human CYP1A2, recombinant CYP1A, CP12, P3-450, P450(PA)
Gene Symbol CYP1A2
Gene ID 1544
Accession # P05177
Source Pichia pastoris
Appearance Dry powder
Physical Form Description Lyophilized powder
Molecular Weight 55 Kda
Purity by NA
Endotoxin Level NA
Biological Activity NA
Reconstitution Instructions 100 mM Potassium Phosphate buffer, pH 7.7
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Cytochrome P450 1A2 (CYP1A2, EC 1.14.14.1) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are converted to more hydrophilic products to facilitate excretion from the body. CYP1A2 metabolizes many antidepressants and antipsychotic drugs, some of its substrates being caffeine, acetaminophen, fluvoxamine and Haloperidol. Expression of CYP1A2 appears to be induced by various dietary constituents like cabbages, cauliflower and broccoli. BioVision’s EZCyp™ 1A2 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP1A2 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.


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My protein is not dissolving in 100 mM Potassium Phosphate buffer, pH 7.7. Could you suggest any other buffer or recommend a protocol to reconstitute?
7876-10 is a powder that will not dissolve completely. It is used as a suspension. After the reaction is performed, the tube can be centrifuged and the supernatant will contain the metabolite. Potassium Phosphate buffer is suitable for resuspension.