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EX-229

A potent AMPK activator
Catalog #: B2434
SKU-Size Size Price Qty
B2434-5 5 mg
$155.00
B2434-25 25 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name EX229, AMPK Activator 991, 5-{[6-chloro-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy}-2-methyl-benzoic acid
Appearance Off-white solid
CAS # 1219739-36-2
Molecular Formula C₂₄H₁₈ClN₃O₃
Molecular Weight 431.87
Purity ≥98% by HPLC
Solubility >5 mg/ml in DMSO
SMILES CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC5=C(C=C4)N(C=C5)C)Cl)C(=O)O
InChi InChI=1S/C24H18ClN3O3/c1-13-3-5-16(10-17(13)23(29)30)31-24-26-20-11-18(19(25)12-21(20)27-24)14-4-6-22-15(9-14)7-8-28(22)2/h3-12H,1-2H3,(H,26,27)(H,29,30)
InChi Key FHWSAZXFPUMKFL-UHFFFAOYSA-N
PubChem CID 45256693
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

EX-229 is a potent and allosteric activator of AMP-activated protein kinase (AMPK). In rat epitrochlearis muscle, ex229 dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes with significant increases in AMPK activity seen at a concentration of 50 μM.


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