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EW-7197

A potent ALK5 inhibitor
Catalog #: B1191
SKU-Size Size Price Qty
B1191-1 1 mg
$95.00
B1191-5 5 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline
Appearance White Solid
CAS # 1352608-82-2 
Molecular Formula C₂₂H₁₈FN₇
Molecular Weight 399.42
Purity ≥98% by HPLC
Solubility DMSO (>75 mg/ml)
SMILES CC1=CC=CC(=N1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4
InChi InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)
InChi Key FJCDSQATIJKQKA-UHFFFAOYSA-N
PubChem CID 54766013
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

EW-7197 is a potent ALK5 (TGF-β Type I receptor) inhibitor that displays anti metastatic activity in vivo. In vivo mice experiments show EW-7197 repeals TGF- β1 induced tumor cell migration and invasion inhibiting breast cancer metastasis to the lung. It prolongs the life span of BALB/c4T1 mice by inhibiting metastasis and enhancing the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotropic grafted mice.


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