A topoisomerase II inhibitor

WARNING: This product can expose you to chemicals including Etoposide, which is [are] known to the State of California to cause cancer.  For more information go to
Catalog #: 1043 | abID:

Product Details

Alternate Name 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside, VP-16-213
Appearance • Liquid
• Solid
Formulation • 1043-100 (100 mM in DMSO)
• 1043-25MG (Solid)
• 1043-250MG (Solid)
CAS # 33419-42-0
Molecular Formula C₂₂H₂₉FO₅
Molecular Weight 588.56
Purity >98% by HPLC
Solubility DMSO ( 25 mg/ml)
InChi InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
PubChem CID 36462
MDL Number MFCD00869325
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A topoisomerase II inhibitor. A derivative of podophyllotoxin that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in human T cells, mouse thymocytes, and HL-60 human leukemia cells

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.
Rasha A. Mansouri, Cranberry extract initiates intrinsic apoptosis in HL-60 cells by increasing BAD activity through inhibition of AKT phosphorylation. BMC Complement Med Ther., Mar. 2020;  32143616.
Patrick T. Fueger et al., Mitogen-Inducible Gene 6 Triggers Apoptosis and Exacerbates ER Stress-Induced β-Cell Death. Mol. Endocrinol., Jan 2013; 27: 162 - 171
Itamochi, H. et. al. Inhibiting the mTOR Pathway Synergistically Enhances Cytotoxicity in Ovarian Cancer Cells Induced by Etoposide through Upregulation of c-Jun. Clin. Cancer Res., Jul 2011; 17: 4742 - 4750.
Xia, H. F. et. al. Retinoic acid metabolizing enzyme CYP26A1 is implicated in rat embryo implantation. Hum. Reprod., Dec 2010; 25: 2985 - 2998.
Bhola, P, Simon, S. Determination and Divergence of Apoptosis Susceptibility in Mammalian Cells. J. Cell Sci. 2009; 122: 4296-4302.
For more citations of this product click here