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Etoposide

based on 7 citations in multiple journalsEtoposide74.1 4
A topoisomerase II inhibitor
Catalog #: 1043
SKU-Size Size Price Qty
1043-100 100 µl
$85.00
1043-25MG 25 mg
$95.00
1043-250MG 250 mg
$425.00
More Sizes Get Quote

Product Details

Alternate Name 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside, VP-16-213
Appearance • Liquid
• Solid
Formulation • 1043-100 (100 mM in DMSO)
• 1043-25MG (Solid)
• 1043-250MG (Solid)
CAS # 33419-42-0
Molecular Formula C₂₂H₂₉FO₅
Molecular Weight 588.56
Purity >98% by HPLC
Solubility DMSO ( 25 mg/ml)
SMILES CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
InChi InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
InChi Key VJJPUSNTGOMMGY-MRVIYFEKSA-N
PubChem CID 36462
MDL Number MFCD00869325
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A topoisomerase II inhibitor. A derivative of podophyllotoxin that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in human T cells, mouse thymocytes, and HL-60 human leukemia cells


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Patrick T. Fueger et al., Mitogen-Inducible Gene 6 Triggers Apoptosis and Exacerbates ER Stress-Induced β-Cell Death. Mol. Endocrinol., Jan 2013; 27: 162 - 171
Itamochi, H. et. al. Inhibiting the mTOR Pathway Synergistically Enhances Cytotoxicity in Ovarian Cancer Cells Induced by Etoposide through Upregulation of c-Jun. Clin. Cancer Res., Jul 2011; 17: 4742 - 4750.
Xia, H. F. et. al. Retinoic acid metabolizing enzyme CYP26A1 is implicated in rat embryo implantation. Hum. Reprod., Dec 2010; 25: 2985 - 2998.
Bhola, P, Simon, S. Determination and Divergence of Apoptosis Susceptibility in Mammalian Cells. J. Cell Sci. 2009; 122: 4296-4302.
Jensen H et al (2009) J. Leukoc. Biol.; 10.1189/jlb.0209056.
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