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Ethynylcytidine

An anticancer agent
Catalog #: B1266
SKU-Size Size Price Qty
B1266-5 5 mg
$135.00
B1266-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name 1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine; TAS-106
Appearance Crystaline solid
CAS # 180300-43-0
Molecular Formula C₁₁H₁₃N₃O₅ 
Molecular Weight 267.24
Purity ≥98% by HPLC
Solubility DMSO
SMILES C#CC1(C(OC(C1O)N2C=CC(=NC2=O)N)CO)O
InChi InChI=1S/C11H13N3O5/c1-2-11(18)6(5-15)19-9(8(11)16)14-4-3-7(12)13-10(14)17/h1,3-4,6,8-9,15-16,18H,5H2,(H2,12,13,17)/t6-,8+,9-,11-/m1/s1
InChi Key JFIWEPHGRUDAJN-DYUFWOLASA-N
PubChem CID 176885
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. Ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis. 


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