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Ethanolamine Kinase 2, human recombinant

Catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate
Catalog #: P1158
$355.00

Product Details

Cat # +Size P1158-10
Size 10 μg
Alternate Name Ethanolamine Kinase 2, ETNK2, EKI2, ethanolamine phosphokinase, Ethanolamine kinase-like protein
Gene Symbol ETNK2
Gene ID 55224
Accession # Q9NVF9
Source E.coli
Appearance Liquid
Physical Form Description In 20 mM Tris, pH 8.0, 150 mM NaCl, 2 mM DTT, 2 mM EDTA and 20% glycerol
Molecular Weight 45 kDa
Purity by SDS-PAGE > 90%
Biological Activity Specific activity is ≥ 2 mU/mg
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Ethanolamine kinase, ETNK, (E.C. 2.7.1.82), catalyzes the ATP-dependent phosphorylation of free intracellular ethanolamine and this is the first committed step of the de novo CDP-ethanolamine pathway for phosphatidylethanolamine (PE) biosynthesis in mammalian tissues. PE is a major phospholipid component of cell membranes and it is involved in diacylglyercol and G protein-dependent signal transduction. ETNK plays a critical role in cell growth and it is implicated to associate with abnormal choline and ethanolamine phospholipid metabolism identified in breast, prostate, ovarian and cervical cancers. Two isoforms of ethanolamine kinase, ETNK1 and ETNK2, have been identified in mammalian cells and they share > 50% in homology. BioVision’s active human ETNK2 is suitable for functional assays, high-throughput screening and preclinical studies in drug discovery.


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