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Erlotinib, Hydrochloride Salt

based on 2 citations in multiple journalsErlotinib, Hydrochloride Salt24.1 4
An EGFR kinase inhibitor
Catalog #: 1588
SKU-Size Size Price Qty
1588-100 100 mg
$110.00
1588-1000 1 g
$320.00
More Sizes Get Quote

Product Details

Alternate Name CP-358774, OSI-774
Appearance White to off-white solid
CAS # 183319-69-9
Molecular Formula C₂₂H₂₃N₃O₄.HCl
Molecular Weight 429.9
Purity ≥99% by HPLC
Solubility DMSO
SMILES COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
InChi InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
InChi Key GTTBEUCJPZQMDZ-UHFFFAOYSA-N
PubChem CID 176871
MDL Number MFCD07781272
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Erlotinib is an inhibitor of human Epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC₅₀ = 20 nM). Studies in cell lines and enzyme assays have both shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl.


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Cheng et al., The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion. Mol. Cancer Res., Mar 2015; 13: 575 - 583.
Dayekh et al., Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors. Mol. Cancer Ther., Nov 2014; 13: 2559 - 2571.
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