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Erdafitinib

A potent pan fibroblast growth factor receptor (FGFR) inhibitor
Catalog #: B2458

In stock

SKU-Size Size Price Qty
B2458-5 5 mg
$85.00
B2458-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name N1-(3,5-dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)ethane-1,2-diamine; JNJ-42756493; JNJ42756493; JNJ 42756493
Appearance Beige to pale yellow solid
CAS # 1346242-81-6
Molecular Formula C₂₅H₃₀N₆O₂
Molecular Weight 446.55
Purity ≥98% by HPLC
Solubility >30 mg/ml DMSO
SMILES CC(C)NCCN(C1=CC2=NC(=CN=C2C=C1)C3=CN(N=C3)C)C4=CC(=CC(=C4)OC)OC
InChi InChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23) 18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3
InChi Key OLAHOMJCDNXHFI-UHFFFAOYSA-N
PubChem CID 67462786
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Erdafitinib is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. It inhibits FGFR1/2/3/4 with IC₅₀s of 1.2, 2.5, 3.0 and 5.7 nM, respectively.


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