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EPZ015866 (GSK591)

A potent selective inhibitor of the arginine methyltransferase PRMT5/MEP50 complex
Catalog #: B1216
SKU-Size Size Price Qty
B1216-5 5 mg
B1216-25 25 mg
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Product Details

Alternate Name (S)-2-(cyclobutylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide
Appearance Crystalline solid
CAS # 1616391-87-7
Molecular Formula C₂₂H₂₈N₄O₂
Molecular Weight 380.5
Purity ≥98% by HPLC
Solubility DMSO(>40 mg/ml)
InChi InChI=1S/C22H28N4O2/c27-20(15-26-11-9-16-4-1-2-5-18(16)14-26)13-24-22(28)17-8-10-23-21(12-17)25-19-6-3-7-19/h1-2,4-5,8,10,12,19-20,27H,3,6-7,9,11,13-15H2,(H,23,25)(H,24,28)/t20-/m0/s1
PubChem CID 117072552
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


EPZ015866 (GSK591) is a potent selective inhibitor of the arginine methyltransferase PRMT5/MEP50 complex thus stopping the methylation of histone H4 with IC₅₀ of 11 nM. It also maintains superior selectivity against other panels of methyl transferases inhibiting the symmetric arginine methylation of SmD3 with EC₅₀ of 56 nM.

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