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EPZ011989

A potent EZH2 inhibitor
Catalog #: B1221
SKU-Size Size Price Qty
B1221-5 5 mg
$165.00
B1221-25 25 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((1r,4r)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide
Appearance Off-white solid
CAS # 1598383-40-4
Molecular Formula C₃₅H₅₁N₅O₄ 
Molecular Weight 605.82
Purity ≥98% by HPLC
Solubility DMSO(>10 mg/ml)
SMILES CCN(C1CCC(CC1)N(C)CCOC)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C#CCN4CCOCC4
InChi InChI=1S/C35H51N5O4/c1-7-40(30-12-10-29(11-13-30)38(5)15-18-43-6)33-23-28(9-8-14-39-16-19-44-20-17-39)22-31(27(33)4)34(41)36-24-32-25(2)21-26(3)37-35(32)42/h21-23,29-30H,7,10-20,24H2,1-6H3,(H,36,41)(H,37,42)
InChi Key XQFINGFCBFHOPE-UHFFFAOYSA-N
PubChem CID 73670548
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

EPZ011989 is a potent EZH2 inhibitor with Ki values that are less than 3 nM for wild type and Tyr646 mutated EZH2. It displays 15-fold selectivity for EZH2 over EZH1 and is without effect against an array of other lysine methyltransferases. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.


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