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EPZ004777

A potent DOT1L inhibitor
Catalog #: 2381
SKU-Size Size Price Qty
2381-1 1 mg
$115.00
2381-5 5 mg
$395.00
More Sizes Get Quote

Product Details

Alternate Name 1-(3-((((2R,3S,4R,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea
Appearance Crystalline solid
CAS # 1338466-77-5
Molecular Formula C₂₈H₄₁N₇O₄
Molecular Weight 539.67
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C3N=CN=C4N)O)O
InChi InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21?,22-,23-,26?/m1/s1
InChi Key WXRGFPHDRFQODR-QQNJPBSNSA-N
PubChem CID 70702060
Handling Protect from light and air
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent and selective DOT1L inhibitor. Treatment of leukemic cells with EPZ004777 results in selective killing of those cells bearing the MLL (mixed lineage leukemia) gene translocation, with little effect on non-MLL-translocated cells.


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