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EPZ-6438

A potent EZH2 inhibitor
Catalog #: 2383
SKU-Size Size Price Qty
2383-5 5 mg
$150.00
2383-25 25 mg
$560.00
More Sizes Get Quote

Product Details

Alternate Name N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide; E-7438
Appearance Crystalline solid
CAS # 1403254-99-8
Molecular Formula C₃₄H₄₄N₄O₄
Molecular Weight 572.74
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
SMILES CCN(C1CCOCC1)C2=CC(C3=CC=C(CN4CCOCC4)C=C3)=CC(C(NCC5=C(C)C=C(C)NC5=O)=O)=C2C
InChi InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
InChi Key NSQSAUGJQHDYNO-UHFFFAOYSA-N
Handling Protect from light and air
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent and selective inhibitor of histone methyltransferase EZH2. EPZ-6438 specifically inhibits cellular H3K27 methylation leading to selective apoptotic killing of SMARCB1 mutant MRT cells. It also induces neuronal differentiation and cell cycle inhibition while suppressing expression of Hedgehog (Hh) pathway genes.


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