Product Details
| Alternate Name | N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide; GSK3235025 |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1616391-65-1 |
| Molecular Formula | C₂₀H₂₅N₅O₃ |
| Molecular Weight | 383.44 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~ 30 mg/ml) |
| SMILES | C1CN(CC2=CC=CC=C21)CC(CNC(=O)C3=CC(=NC=N3)NC4COC4)O |
| InChi | InChI=1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4,7,13,16-17,26H,5-6,8-12H2,(H,21,27)(H,22,23,24)/t17-/m0/s1 |
| InChi Key | ZKXZLIFRWWKZRY-KRWDZBQOSA-N |
| PubChem CID | 90241673 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
EPZ015666 is a potent, selective PRMT5 inhibitor (Ki of 5 nM); displays >20,000-fold selectivity over other PMTs. EPZ015666 acts by blocking the association of PRMT5 with methylosome protein 50, which is necessary for the formation of an active methyltransferase complex.
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