A potent and selective PRMT5 inhibitor
Catalog #: 9410 | abID:

Product Details

Alternate Name N-​[(2S)-​3-​(3,​4-​dihydro-​2(1H)-​isoquinolinyl)-​2-​hydroxypropyl]-​6-​(3-​oxetanylamino)-​4-​pyrimidinecarboxamide; GSK3235025
Appearance Crystalline solid
CAS # 1616391-65-1
Molecular Formula C₂₀H₂₅N₅O₃
Molecular Weight 383.44
Purity ≥98% by HPLC
Solubility DMSO (~ 30 mg/ml)
InChi InChI=1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4,7,13,16-17,26H,5-6,8-12H2,(H,21,27)(H,22,23,24)/t17-/m0/s1
PubChem CID 90241673
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


EPZ015666 is a potent, selective PRMT5 inhibitor (Ki of 5 nM); displays >20,000-fold selectivity over other PMTs. EPZ015666 acts by blocking the association of PRMT5 with methylosome protein 50, which is necessary for the formation of an active methyltransferase complex.

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