Product Details
| Alternate Name | N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl- 1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-threoninamide; BU-4061T |
|---|---|
| Appearance | White solid |
| CAS # | 134381-21-8 |
| Molecular Formula | C₂₈H₅₀N₄O₇ |
| Molecular Weight | 554.7 |
| Purity | ≥95% by HPLC |
| Solubility | DMSO (~ 10 mg/ml) |
| SMILES | CCC(C)C(C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)C1(CO1)C)NC(=O)C(C(C)CC)N(C)C(=O)C |
| InChi | InChI=1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,33H,11-14H2,1-10H3,(H,29,37)(H,30,38)(H,31,36)/t16-,17-,18+,20-,21-,22-,23-,28+/m0/s1 |
| InChi Key | DOGIDQKFVLKMLQ-JTHVHQAWSA-N |
| PubChem CID | 11226684 |
| MDL Number | MFCD03791061 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent inhibitor of the chymotrypsin-like activity of the proteasome than Lactacystin (Cat. No. 1709-100). Blocks also trypsin-like and PGPH activities of the proteasome.
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