A potent proteasome inhibitor
Catalog #: 2190 | abID:

Product Details

Alternate Name N-​acetyl-​N-​methyl-​L-​isoleucyl-​L-​isoleucyl-​N-​[(1S)-​3-​methyl-​ 1-​[[(2R)-​2-​methyloxiranyl]carbonyl]butyl]-​L-​threoninamide; BU-4061T
Appearance White solid
CAS # 134381-21-8
Molecular Formula C₂₈H₅₀N₄O₇
Molecular Weight 554.7
Purity ≥95% by HPLC
Solubility DMSO (~ 10 mg/ml)
InChi InChI=1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,33H,11-14H2,1-10H3,(H,29,37)(H,30,38)(H,31,36)/t16-,17-,18+,20-,21-,22-,23-,28+/m0/s1
PubChem CID 11226684
MDL Number MFCD03791061
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent inhibitor of the chymotrypsin-like activity of the proteasome than Lactacystin (Cat. No. 1709-100). Blocks also trypsin-like and PGPH activities of the proteasome.

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