Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Epothilone B

A microtubule depolymerization inhibitor and an anticancer agent
Catalog #: 2012
SKU-Size Size Price Qty
2012-1 1 mg
$80.00
2012-5 5 mg
$310.00
More Sizes Get Quote

Product Details

Alternate Name EPO-906; EpoB; Patupilone
Appearance White to off-white solid
CAS # 152044-54-7
Molecular Formula C₂₇H₄₁NO₆S
Molecular Weight 507.68
Purity ≥98% by HPLC
Solubility DMSO (40 mg/ml) or EtOH (40 mg/ml)
SMILES CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C
InChi InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
InChi Key QXRSDHAAWVKZLJ-PVYNADRNSA-N
PubChem CID 448013
MDL Number MFCD02101921
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A macrolide anticancer agent. Similar to paclitaxel (Cat. No. 1567-25), epothilone B induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Also induces G2-M cell cycle arrest (EC₅₀= 3 - 92 nM).


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.