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EPO-alpha, human recombinant

A glycoprotein hormone that controls erythropoiesis
Catalog #: 4763
SKU-Size Size Price Qty
4763-10 10 μg
$185.00
4763-50 50 μg
$595.00
4763-1000 1 mg
$4,950.00
More Sizes Get Quote

Product Details

Alternate Name Erythropoietin-α, EPO-α, Epoetin, EP, MGC138142
Gene Symbol Epo
Gene ID 2056
Accession # P01588
Source CHO cells
Appearance Lyophilized protein
Physical Form Description Each mg of lyophilized protein contains 0.58 mg sodium citrate, 0.58 mg sodium chloride and 0.006 mg citric acid.
Molecular Weight 37 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥90%
Endotoxin Level <0.1 ng/μg
Biological Activity Determined by a cell proliferation assay using TF-1 cells. The expected ED50 for this effect is 0.8-1.0 ng/ml.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1 to 1.0 mg/ml. This solution can then be diluted into other aqueous buffers containing a carrier protein (like 0.1% BSA) and stored in working aliquots at -20°C to -80ºC
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. The differentiation of CFU-E (Colony Forming Unit -Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation of smooth muscle, neural protection during hypoxia, and stimulation of certain B cells. BioVision’s Human EPO contains 166 amino acid residues and has a calculated molecular weight of approximately 18.4 kDa. As a result of glycosylation, Recombinant Human EPO migrates with an apparent molecular mass of 37.0 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.


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Xia, Ning et al. (2017) Design of electrochemical biosensors with peptide probes as the receptors of targets and the inducers of gold nanoparticles assembly on electrode surface, Sensors and Actuators B: Chemical. 2017 Feb,239:834-840
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