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Enzastaurin (LY317615)

A PKC beta inhibitor
Catalog #: 1619
SKU-Size Size Price Qty
1619-1 1 mg
$155.00
1619-5 5 mg
$520.00
More Sizes Get Quote

Product Details

Alternate Name LY317615, LY-317615, D04014
Appearance Red-Orange Solid
CAS # 170364-57-5
Molecular Formula C₃₂H₂₉N₅O₂
Molecular Weight 515.61
Purity ≥99% by HPLC
Solubility DMSO (5 mg/ml)
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7
InChi InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
InChi Key AXRCEOKUDYDWLF-UHFFFAOYSA-N
PubChem CID 176167
MDL Number MFCD11040980
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Enzastaurin (Enz) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC₅₀= ~6 nM). Enz suppresses VEGF-induced angiogenesis in the rat corneal micropocket assay, decreases microvessel density, and prevents VEGF secretion from human tumor cell xenografts in nude mice. Prolonged courses of Enz increase chemotherapy or radiation tumor growth delay of glioma, breast, and small cell lung cancer xenografts.


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