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A potent anaplastic lymphoma kinase (ALK) inhibitor
Catalog #: B1946
SKU-Size Size Price Qty
B1946-5 5 mg
B1946-25 25 mg
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Product Details

Alternate Name (R)-6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide; X396
Appearance Crystalline solid
CAS # 1365267-27-1
Molecular Formula C₂₅H₂₅Cl₂FN₆O₃
Molecular Weight 547.41
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14H,9-12H2,1-2H3,(H2,29,32)(H,30,35)/t14-/m1/s1
PubChem CID 56960447
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Ensartinib (X-396), is a potent, small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Ensartinib has been active in animal models of non-small cell lung cancer (NSCLC) and neuroblastoma. Also, ensartinib has shown activity in models with ALK mutations that confer resistance to other small molecule ALK inhibitors.

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