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Endostatin, human recombinant

An anti-angiogenic agent
Catalog #: 4759
SKU-Size Size Price Qty
4759-20 20 μg
$85.00
4759-100 100 μg
$180.00
4759-1000 1 mg
$1,100.00
More Sizes Get Quote

Product Details

Alternate Name Collagen alpha-1(XVIII) chain, Endostatin-XV, Related to endostatin, Restin
Gene Symbol COL18A1
Gene ID 80781
Accession # P39060
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized from 50 mM Tris, pH 8.0
Molecular Weight 20.5 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level <0.1 ng/μg
Reconstitution Instructions Reconstitute with sterile dH₂O to a concentration ≥ 1.0 mg/ml, aliquot and store at below –20°C. Avoid freeze-thaw cycles.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant human Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.


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