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Endostatin, human recombinant

An anti-angiogenic agent
Catalog #: 4799
SKU-Size Size Price Qty
4799-100 100 μg
$190.00
4799-1000 1 mg
$1,675.00
More Sizes Get Quote

Product Details

Alternate Name Collagen alpha-1(XVIII) chain
Source Pichia Pastoria
Appearance Liquid
Physical Form Description Sterile filtered liquid
Molecular Weight 20.0 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity BioVision’s human Endostatin is biologically active when compared to standards. The activity as calculated by ECE migration inhibition was found to be 50,000 IU/mg.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.DESCRIPTION: Recombinant Human Endostatin produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Induces tyrosine phosphorylation of Shc (SH2 domain adapter protein) leading to specific inhibition in endothelial cell proliferation.


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