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Emricasan

A caspase inhibitor
Catalog #: B2596
SKU-Size Size Price Qty
B2596-5 5 mg
$95.00
B2596-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name (S)-3-((S)-2-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid, PF-03491390, IDN-6556
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 254750-02-2
Molecular Formula C₂₆H₂₇F₄N₃O₇
Molecular Weight 569.5
Purity ≥98% by HPLC
Solubility ~30 mg/ml in DMSO
SMILES CC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C
InChi InChI=1S/C26H27F4N3O7/c1-12(31-24(38)25(39)32-16-8-6-5-7-13(16)26(2,3)4)23(37)33-17(10-19(35)36)18(34)11-40-22-20(29) 14(27)9-15(28)21(22)30/h5-9,12,17H,10-11H2,1-4H3,(H,31,38)(H,32,39)(H,33,37)(H,35,36)/t12-,17-/m0/s1
InChi Key SCVHJVCATBPIHN-SJCJKPOMSA-N
PubChem CID 12000240
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Emricasan (PF-03491390) is an irreversible pan-caspase inhibitor. In a mouse model of α-Fas-induced acute liver injury, the orally-administered caspase inhibitor Emricasan was retained in the liver for prolonged periods with a low systemic exposure.


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