Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

EML-425

A potent, reversible and non-competitive dual CBP and p300 inhibitor
Catalog #: B1882
SKU-Size Size Price Qty
B1882-5 5 mg
$275.00
B1882-25 25 mg
$1,095.00
More Sizes Get Quote

Product Details

Alternate Name 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Appearance Yellow solid
CAS # 1675821-32-5 
Molecular Formula C₂₇H₂₄N₂O₄
Molecular Weight 440.49
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES O=C1N(CC2=CC=CC=C2)C(/C(C(N1CC3=CC=CC=C3)=O)=C\C4=C(C)C=C(O)C=C4C)=O
InChi InChI=1S/C27H24N2O4/c1-18-13-22(30)14-19(2)23(18)15-24-25(31)28(16-20-9-5-3-6-10-20)27(33)29(26(24)32)17-21-11-7-4-8-12-21/h3-15,30H,16-17H2,1-2H3
InChi Key  LUGQBJDYUPNAQQ-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

EML-425 is a potent, reversible and non-competitive dual CBP and p300 inhibitor (IC₅₀ values are 1.1 and 2.9 μM, respectively).  EML425 induced a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9, a marked arrest in the G0/G1 phase and a significant increase in the hypodiploid nuclei percentage in human leukemia U937 cells. Cell-permeable.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.