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A potent, reversible and non-competitive dual CBP and p300 inhibitor
Catalog #: B1882
SKU-Size Size Price Qty
B1882-5 5 mg
B1882-25 25 mg
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Product Details

Alternate Name 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Appearance Yellow solid
CAS # 1675821-32-5 
Molecular Formula C₂₇H₂₄N₂O₄
Molecular Weight 440.49
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
InChi InChI=1S/C27H24N2O4/c1-18-13-22(30)14-19(2)23(18)15-24-25(31)28(16-20-9-5-3-6-10-20)27(33)29(26(24)32)17-21-11-7-4-8-12-21/h3-15,30H,16-17H2,1-2H3
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


EML-425 is a potent, reversible and non-competitive dual CBP and p300 inhibitor (IC₅₀ values are 1.1 and 2.9 μM, respectively).  EML425 induced a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9, a marked arrest in the G0/G1 phase and a significant increase in the hypodiploid nuclei percentage in human leukemia U937 cells. Cell-permeable.

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