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Product Details
| Alternate Name | 2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 316-42-7 |
| Molecular Formula | C₂₉H₄₀N₂O₄·2HCl |
| Molecular Weight | 553.56 |
| Purity | ≥98% by titration |
| Solubility | Water (~ 100 mg/ml) |
| SMILES | CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.Cl.Cl |
| InChi | InChI=1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1 |
| InChi Key | JROGBPMEKVAPEH-GXGBFOEMSA-N |
| PubChem CID | 3068143 |
| MDL Number | MFCD00135589 |
| Handling | Protect from light and moisture |
| Storage Conditions | 4°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures. It has been found to inhibit endemic human coronaviruses and MERS-CoV in cell culture and cell entry assays.
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