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Emetine dihydrochloride hydrate

A protein synthesis inhibitor
Catalog #: B2339

In stock

SKU-Size Size Price Qty
B2339-50 50 mg
$85.00
B2339-250 250 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name (2S,3R,11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine, dihydrochloride, hydrate,Emetine hydrochloride hydrate
Appearance White to off-white solid
CAS # 7083-71-8
Molecular Formula C₂₉H₄₀N₂O₄.2HCl. xH₂O
Molecular Weight 553.56 (anhydrous basis)
Purity ≥98% by HPLC
Solubility >100 mg/ml (H₂O)
SMILES CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.O.Cl.Cl
InChi InChI=1S/C29H40N2O4.2ClH.H2O/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H;1H2/t18-,21-,24+,25-;;;/m0.../s1
InChi Key IZTPMTAWOCEKKM-VXMYZLRESA-N
PubChem CID 201899
MDL Number MFCD00149309
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Emetine dihydrochloride is an alkaloid, derived from ipecac root. Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.


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