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A potent microtube disruptor
Catalog #: 9433
SKU-Size Size Price Qty
9433-5 5 mg
9433-25 25 mg
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Product Details

Alternate Name N-​​[5-​​(5-​​cyano-​​2-​​thienyl)​-​​2-​​methylphenyl]​-​​4-​​methyl-​benzenesulfonamide
Appearance Crystalline solid
CAS # 1233948-35-0
Molecular Formula C₁₉H₁₆N₂O₂S₂
Molecular Weight 368.5
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C19H16N2O2S2/c1-13-3-8-17(9-4-13)25(22,23)21-18-11-15(6-5-14(18)2)19-10-7-16(12-20)24-19/h3-11,21H,1-2H3
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


ELR-510444 is a potent microtube disruptor with potential anticancer activity. It displays potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. ELR-510444 potently inhibits cell proliferation with an IC₅₀ value of 30.9 nM in MDA-MB-231 cells, inhibits the rate and extent of purified tubulin assembly, and displaces colchicine from tubulin, indicating that the drug directly interacts with tubulin at the colchicine-binding site.

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