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A potent and selective HDAC11 inhibitor
Catalog #: B1893

Product Details

Cat # +Size B1893-1
Size 1 mg
Alternate Name JB3-22; HDAC11i; HDAC11 inhibitor
Appearance White solid
Molecular Weight 315.33
Purity ≥95%
Solubility DMSO
InChi InChi=1S/C16H17N3O4/c1-23-14-5-3-2-4-13(14)18-16(21)17-10-11-6-8-12(9-7-11)15(20)19-22/h2-9,22H,10H2,1H3,(H,19,20)(H2,17,18,21)
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Elevenostat (JB3-22), is a small molecule hydroxamic acid derivative that acts as a HDAC11-selective inhibitor. Reporter assays using a luciferase-linked Foxp3 promoter shows that HDAC11 decreases the signal driven by NFκB/p65, alone or in the presence of transfected Foxp3, and impairs luciferase activity driven by p65, Foxp3 and the HAT enzyme, p300. The inhibitory effects of HDAC11 at the Foxp3 promoter are reversed by Elevenostat (JB3-22), (IC₅₀ 0.235 µM). Elevenostat also partially reverses the inhibitory effect of HDAC11 on p300-induced Foxp3 acetylation at lysine 31 consistent with the ability of HDAC11 to directly regulate acetylation of Foxp3.

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