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Elastase Inhibitor

A potent, irreversible human leukocyte elastase (HLE) inhibitor
Catalog #: 1922

Product Details

Cat # +Size 1922-5
Size 5 mg
Alternate Name MeOSuc-Ala-Ala-Pro-Ala-chloromethylketone; MeOSuc-AAPA-CMK
Appearance White solid
CAS # 111682-13-4
Molecular Formula C₂₀H₃₁ClN₄O₇
Molecular Weight 474.94
Purity ≥98% by TLC
Solubility DMSO
InChi InChI=1S/C20H31ClN4O7/c1-11(22-16(27)7-8-17(28)32-4)18(29)23-12(2)19(30)24-20(31)14-6-5-9-25(14)13(3)15(26)10-21/h11-14H,5-10H2,1-4H3,(H,22,27)(H,23,29)(H,24,30,31)/t11-,12-,13-,14-/m0/s1
PubChem CID 5748191
MDL Number MFCD00238296
Handling Protect from air and mositure
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent, irreversible inhibitor of human neutrophil elastase (HNE). The structure of the enzyme-inhibitor complex reveals crosslinking of the catalytic residues His-57 and Ser-195 by the peptidyl chloromethylketone.

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