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Elastase, Human Neutrophil

Breaks down elastin
Catalog #: 4716

Product Details

Cat # +Size 4716-100
Size 100 µg
Alternate Name Leukocyte Elastase, ELA2
Gene Symbol ELANE
Gene ID 1991
Accession # P08246
Source Human Neutrophil
Appearance Lyophilized protein
Physical Form Description Salt- free lyophilized solid
Molecular Weight 29.5 kDa
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Deionized H₂O
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Elastase, like trypsin and chymotrypsin, is a serine protease that also hydrolyses amides and esters. It is produced in the pancreas as an inactive zymogen, proelastase, and activated in the duodenum by trypsin. Elastase is distinctive in that it acts upon elastin.This enzyme degrades elastin, collagen, and proteoglycan and has been implicated in the development of pulmonary emphesema and rheumatoid arthritis.

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Sho Hiroyasu. Granzyme B inhibition reduces disease severity in autoimmune blistering diseases. Nat Commun. Jan 2021. 33436591.
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