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EHop-016

A potent inhibitor of Rac GTPase
Catalog #: 9595
SKU-Size Size Price Qty
9595-5 5 mg
$95.00
9595-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 4-N-(9-ethylcarbazol-3-yl)-2-N-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine
Appearance Pale yellow solid
CAS # 1380432-32-5
Molecular Formula C₂₅H₃₀N₆O
Molecular Weight 430.55
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES CCN1C2=C(C=C(C=C2)NC3=NC(=NC=C3)NCCCN4CCOCC4)C5=CC=CC=C51
InChi InChI=1S/C25H30N6O/c1-2-31-22-7-4-3-6-20(22)21-18-19(8-9-23(21)31)28-24-10-12-27-25(29-24)26-11-5-13-30-14-16-32-17-15-30/h3-4,6-10,12,18H,2,5,11,13-17H2,1H3,(H2,26,27,28,29)
InChi Key AFTZZRFCMOAFCR-UHFFFAOYSA-N
PubChem CID 51031035
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

EHop-016 is an analog of NSC-23766 (Cat. No. 1941) that acts as a potent inhibitor of Rac GTPase (IC₅₀ = 1.1 µM for Rac1). The IC₅₀ of 1.1 μM for Rac inhibition by EHop-016 is ∼100-fold lower than for NSC-23766. EHop-016 is specific for Rac1 and Rac3 at concentrations of ≤5 μM. At higher concentrations, EHop-016 inhibits the close homolog Cdc42.


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