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Eeyarestatin I

An inhibitor of the ERAD (Endoplasmic-reticulum -associated protein degradation) pathway
Catalog #: 9602
SKU-Size Size Price Qty
9602-5 5 mg
$125.00
9602-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
Appearance White to off-white solid
CAS # 412960-54-4
Molecular Formula C₂₇H₂₅Cl₂N₇O₇
Molecular Weight 630.44
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES CC1(C(N(C(=O)N1CC(=O)NN=CC=CC2=CC=C(O2)[N+](=O)[O-])C3=CC=C(C=C3)Cl)N(C(=O)NC4=CC=C(C=C4)Cl)O)C
InChi InChI=1S/C27H25Cl2N7O7/c1-27(2)24(35(40)25(38)31-19-9-5-17(28)6-10-19)34(20-11-7-18(29)8-12-20)26(39)33(27)16-22(37)32-30-15-3-4-21-13-14-23(43-21)36(41)42/h3-15,24,40H,16H2,1-2H3,(H,31,38)(H,32,37)/b4-3+,30-15+
InChi Key JTUXTPWYZXWOIB-LWWHHIEBSA-N
PubChem CID 23947580
MDL Number MFCD00319108
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Eeyarestatin I is an inhibitor of the ERAD (Endoplasmic-reticulum -associated protein degradation) pathway, blocking the degradation of misfolded proteins at a dose of 8 µM. It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3 (atx3). Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the pro-apoptotic protein NOXA.


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