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EED (1- 441aa), Human recombinant

Repressor of gene activity through histone deacetylation
Catalog #: 7667

Product Details

Cat # +Size 7667-25
Size 25 μg
Alternate Name Embryonic Ectoderm Development
Gene Symbol EED
Gene ID 8726
Accession # O75530
Source Insect (SF21) cells (baculovirus expression system)
Appearance Liquid
Physical Form Description 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.
Molecular Weight 53.5 kDa (1- 441 aa + NT His Tag)
Purity by SDS-PAGE ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans


Polycomb protein Embryonic Ectoderm Development (EED) is a WD repeat containing member of the Polycomb-group (PcG) family. The EED protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. EED is an established transcriptional repressor, as a novel NIPP1 interactor. NIPP1 only interacted with full-length EED, whereas two EED interaction domains were mapped to the central and COOH-terminal thirds of NIPP1. In mammalian cells, EED is present as four distinct isoforms, which are believed to be produced by utilizing four distinct, in-frame translation start sites in a common EED mRNA. The extra sex combs (esc) gene of Drosophila and its mammalian homologue embryonic ectoderm development (EED) play pivotal roles in establishing Polycomb-group (Pc-G) mediated transcriptional silencing of regulatory genes during early development. EED/Sox2 regulatory loop contributes to the maintenance of self-renewal in embryonic stem (ES) cells by controlling histone methylation and acetylation. EED has been defined by the inability of embryos homozygous for certain c deletions to develop beyond the early stages of gastrulation.

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