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EBI-2511

A potent and selective EZH2 Inhibitor
Catalog #: B2433

In stock

SKU-Size Size Price Qty
B2433-1 1 mg
$85.00
B2433-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name EBI2511, N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-ethyl-6-(ethyl-(tetrahydro-2H-pyran-4-yl)amino)-2-(1-isopropylpiperidin-4-yl)benzofuran-4-carboxamide
Appearance Crystalline solid
CAS # 2098546-05-3
Molecular Formula C₃₄H₄₈N₄O₄
Molecular Weight 576.77
Purity ≥98% by HPPC
Solubility >25 mg/ml in DMSO
SMILES CCC1=C(C2=C(C=C1N(CC)C3CCOCC3)OC(=C2)C4CCN(CC4)C(C)C)C(=O)NCC5=C(C=C(NC5=O)C)C
InChi InChI=1S/C34H48N4O4/c1-7-26-29(38(8-2)25-11-15-41-16-12-25)19-31-27(18-30(42-31)24-9-13-37(14-10-24)21(3)4)32(26) 34(40)35-20-28-22(5)17-23(6)36-33(28)39/h17-19,21,24-25H,7-16,20H2,1-6H3,(H,35,40)(H,36,39)
InChi Key NYWVSLBALKNFJR-UHFFFAOYSA-N
PubChem CID 133081962
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

EBI-2511 is a highly potent and orally active EZH2 inhibitor with an IC₅₀ of 4 nM for EZH2(A667G). EBI-2511 displays excellent in vivo efficacy in Pfeiffer tumor Xenograft models in mouse and could be useful for the treatment of cancers associated with EZH2 mutations.


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