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Product Details
| Alternate Name | 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-benzenesulfonamide |
|---|---|
| Peptide Sequence | N/A |
| Appearance | Beige solid |
| CAS # | 289483-69-8 |
| Molecular Formula | C₁₇H₁₂N₄O₂S |
| Molecular Weight | 336.37 |
| Purity | ≥98% by HPLC |
| Solubility | >30 mg/ml in DMSO |
| SMILES | CC1=C2C(=CNC2=C(C=C1)NS(=O)(=O)C3=CC=CC(=C3)C#N)C#N |
| InChi | InChI=1S/C17H12N4O2S/c1-11-5-6-15(17-16(11)13(9-19)10-20-17)21-24(22,23)14-4-2-3-12(7-14)8-18/h2-7,10,20-21H,1H3 |
| InChi Key | LWGUASZLXHYWIV-UHFFFAOYSA-N |
| PubChem CID | 196970 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
E7820 is a small molecule sulfonamide derivative with potential antiangiogenic and antitumor activities. E7820 inhibits angiogenesis by suppressing integrin alpha 2, a cell adhesion molecule expressed on endothelial cells. Inhibition of integrin alpha 2 leads to an inhibition of cell-cell interactions, endothelial cell-matrix interactions, vascular endothelial cell proliferation and angiogenesis.
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