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E6AP Antibody

Catalog #: 3744

In stock

$245.00

Product Details

Cat # +Size 3744-100
Size 100 µl
Antibody Target E6AP
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide of human E6AP
Accession # NP_000453.2
Gene ID 7337
Appearance Colorless liquid
Formulation 100 µl purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse
Application Western blot, Immunoprecipitation
Application & Usage Western blotting (1:500 – 1:2500) and immunoprecipitation. However, the optimal concentrations should be determined individually. The antibody recognizes the E6AP of human and mouse origins. Reactivity to other species has not been tested
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

E6AP is an E3 ubiquitin ligase. Inheritance of a mutant maternal copy of this gene results in Angelman syndrome (AS) which is characterized by severe mental retardation, seizures, ataxia, and EEG abnormalities. E6AP interacts with the type 16 and 18 human papillomavirus E6 oncoprotein which results in the targeting of p53 for degradation via the ubiquitin-proteasome system.


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