DUB Inhibitor, NSC-632839

A pan-specific ubiquitin isopeptidase inhibitor
Catalog #: 2570 | abID:

Product Details

Alternate Name 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Appearance Yellow solid
CAS # 157654-67-6
Molecular Formula C₂₁H₂₁NO · HCl
Molecular Weight 339.86
Purity ≥98% by HPLC
Solubility DMSO (~8 mg/ml)
InChi InChI=1S/C21H21NO.ClH/c1-15-3-7-17(8-4-15)11-19-13-22-14-20(21(19)23)12-18-9-5-16(2)6-10-18;/h3-12,22H,13-14H2,1-2H3;1H/b19-11+,20-12+;
PubChem CID 5351362
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A pan-specific ubiquitin isopeptidase inhibitor (IC₅₀ = 45, 37 and 9.8 µM for USP2, USP7 and SENP2 respectively). NSC-632839 does not affect proteasome proteolytic activity. Induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.

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